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Apolact TDC

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Apolact TDC is a patented, unique and innovative food supplement. It contains liposomal Apo-lactoferrin and can be useful for the treatment of lactoferrin deficiency or when increased levels of lactoferrin are needed.

Liposomes are lipid spheres which facilitate the protection and the release of Apo-lactoferrin.

 Apo-lactoferrin (form of lactoferrin without iron) is more active than lactoferrin (up to 5 times more) as it binds to iron through the open form of apo-protein, thus allowing for an easier access of Fe3+ complex ions.
 
Lactoferrin is an iron-chelating protein involved in several biologic mechanisms..
 
It delivers an iron-transfer activity, it belongs to the family of transferrins and has been widely studied for its multiple healthy effects:
  • Antioxidant activity
  • Immunostimulant
  • It maintains the homeostasis of iron
  • Antimicrobic activity
  • Restores the intestinal microbiota
 
However, due its nature Apo-lactoferrin is unstable and is particularly sensitive to the proteolytic activity of pepsin in the gastric tract and to proteolytic hydrolysis in the bowel. This causes the protein denaturation, poor absorption and its inactivation. APOLact TDC, thanks to its modern technology of microencapsulation, overcomes the above problems and is the first advanced formulation that delivers the efficacy of the glycoprotein.
 
Clinical studies have shown that during digestion, the concentration of Apo-lactoferrin incorporated in the liposomes has remained absolutely unchanged over time and was not subject to hydrolysis caused by pepsin in the gastric tract, unlike what happens when the glycoprotein is ingested as is; this suggests that these prepared liposomes are statile and prevent pepsin-induced hydrolysis.
 
In the simulated intestinal fluid, encapsulated Apo-lactoferrin turned out to be sensitive to pancreatin induced hydrolysis, as shown by changes in the diameter and in the structure of the liposome membranes. The release of liposome-f ree fat acids during the simulated intestinal digestion revealed that phospholipids contained in liposomes are subject to partial hydrolysis due to pancreatic lipase. Encapsulation of oral liposomes prevents gastric degradation of the glycoprotein and reduces the speed of hydrolysis in intestinal conditions. 
 
Apo-lactoferrin in lyophilized liposomes:
  • Restoration of the intestinal microbiota: Apo-lactoferrin supports the growth of healthy bacteria and at the same time it inhibits the growth of pathogens (S. aureus, Listeria,H. pylori, E. coli) by chelating iron which is a necessary co-factor for their development. Moreover, since it binds directly to the bacterial component, it prevents their implantation on the intestinal walls thus boosting the natural immune response.
  • Improved iron absorption: Apo-lactoferrin is an iron-carrying protein which maintains the systemic homeostasis of iron. Several studies have proven that its efficacy in case of iron deficiency is substantially superior to other commonly used substances, which are associated with side effects, unlike Apo-lactoferrin.
  • Control of lipid meta bolism: recent studies showed that lactoferrin inhibits lipogenesis, and by doing so it positively regulates lipid meta bolism and contributes to the improvement of liver function. 
 
PACKAGING
30 capsule
 
INGREDIENTS
Each capsule of 550 mg contains 100 mg of Apo-lactoferrin. 
 
DOSAGE
One capsule 1-2 times a day. Maximum dose: 2 capsules a day.
 
WARNINGS
Keep out of reach of children under 3 years. Do not exceed the recommended daily dose. Food supplements are not intended as a substitute for a varied and balanced diet and a healthy lifestyle. Lactoferrin is a protein extracted from cow's milk and therefore is not recommended for use in case of allergyto milk proteins.

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