Skin Collagen® is a biologically active food supplement and a multi-component preparation of substances of natural origin which is useful in all cases of reduced intake on diet or increased need for components useful for the skin and subcutaneous tissue.Thanks to its bioactive components it keeps elastic the skin ensuring the integrity of the hydrolipidic layer, regenerates the elastin and collagen fibers of the dermis. Ensures support to the epidermis in its superficial layers, limits skin aging and counteracts the harmful effects of UV-B rays.
One sachet a day of Skin CollagenÒ can supply:
The particularly balanced formulation plays a positive role in the balance of the subcutaneous tissue, tanks to molecules essential for maintaining skin function and selected plant extracts to protect the skin from oxidative stress.
HYDROLYZED PIG COLLAGEN : THE NUTRITION OF SUBCUTIS
Made up of bioactive peptides got from the enzymatic hydrolysis of highly compatible pig collagen (CH), it contributes to the nourishment and regeneration of the subcutaneous tissue, helping to reduce, prevent and slow down the deterioration of the skin and the phenomena of skin aging.Bioavailability studies have shown that CH is completely assimilable (92% in 12 hours!) providing significant levels of hydroxyproline, an exclusive amino acid of collagen.1The oral intake of bioactive peptides obtained from collagen stimulates chondrocytes to synthesize new collagen together with other components of the extracellular matrix of the cartilage tissue.2These results suggest that CH can reduce changes related to aging of the extracellular matrix by stimulating the anabolic processes in the skin tissue.3In vivo studies indicate that the intake of bioactive peptides obtained from the enzymatic hydrolysis of pig collagen stimulates the regeneration and reduces the signs of aging, generating a significant increase in the concentration of fibroblasts and the diameter and density of the collagen fibers of the skin.4Its benefits in combating photo-aging, protecting against UV-B radiation, preventing wrinkles and increasing skin tone have also been demonstrated.5Clinical studies show that the continuous intake of collagen improves the skin's property, increasing the degree of hydration, elasticity, brightness and density with a significant reduction in the number and size of wrinkles 6-11
POOL OF ANTIOXIDANTS INDICATED IN ANTI-AGING COSMETOLOGY
Natural biocomposites well known for their benefits for the skin: UV radiation protection, wrinkles prevention and skin tone, skin solids reduction , dehydration, dyschromia and other aesthetic changes, in addition to their antioxidant and anti-inflammatory action
Superoxide dismutase is an enzymatic antioxidant naturally present in our body where it neutralizes the anion, a very active and harmful radical.It is an important antioxidant defense in almost all cells exposed to oxygen, such as skin cells12 . It has an anti-aging13 and antioxidant action thanks to its ability to reduce the damage of free radicals in the skin, preventing wrinkles, fine lines, age spots, helping heal wounds, soften scar tissue, promoting UV protection and reducing other signs of aging 14.
Cavacurmin® curcuminis an extract of Curcuma longa L. (15% curcuminoids) complexed with gamma cyclodextrin, which can increase the bioavailability and absorption of Curcumin.Curcumin has proved to be able to counteract inflammation and cellular oxidation. Curcuminoids, bioactive compounds of turmeric with a strong antioxidant action, are able to protect cells from UV-B rays and inhibit the side effects of photosensitivity.15The health benefits of curcumin are limited by its low solubility in water and the comparatively poor intestinal absorption.Curcumin linked to cyclodextrins (Cavacurmin®) shows a noticeable improvement in the solubility, dispersibility and aqueous absorption of curcuminoids.In a recent study on Cavacurmin®, a 39-fold increase in the bioavailability of curcuminoidswas established compared to those deriving from conventional extracts 16
Thelicopeneis a natural substance found in some plant origin foods, especially in tomatoes; it belongs to the group of carotenoids and has remarkable antioxidant properties.It provides several benefits to the skin of the face, including a significant improvement in the appearance of fine lines, wrinkles melanogenesis and counteracts the harmful effects of UV-B rays 17 The skin is particularly exposed to oxidative stress, environmental insults such as sunlight or pollution and to the imbalance of the oxidative state as a consequence of pathologies or aging.In addition to providing exogenous antioxidant products, a modern approach is based on the stimulation and growth of endogenous, enzymatic and non-enzymatic antioxidants.
Resveratrol is a polyphenol belonging to the class of stilbenes. Besides the antioxidant power and the doses present in the formulation, resveratrol is able to carry out an anti-inflammatory action through the inhibition of cyclooxygenase and hydroperoxidase and to stimulate the immune system, promoting in a dose-dependent manner both the production of interleukin II and the antibody production by lymphocytes.Studies carried out on human keratinocytes have shown that resveratrol is able to increase levels of endogenous antioxidants such as glutathione and superoxydismutases and to carry out a dermoprotective action against free radicals and UV rays -B 18-19
PLANTS OF AYURVEDA TRADITION: DEEP SKIN INTEGRATION
Ayurveda is one of the oldest medical traditions practiced in India, Sri Lanka and other countries of South Asia and has a solid philosophical and experiential basis.Ayurveda has different formulations for managing aging and related conditions. His literature describes over 200 herbs, minerals and fats to maintain and improve the health and beauty of the skin.
In order to maintain young the skin, skin care products should be used in order to nourish and rehydrate the skin, otherwise it may be subject to wrinkles and premature aging. In Ayurveda the concept of anti-aging is embodied in the rasayana. Tvagrasayana literally means "rasayana skin", which refers to refined and powerful herbal formulas designed to prevent diseases and skin aging.
Phyllantusemblica (amalaki)isa powerful antioxidant, rich in vitamin C, tannins and gallic acid, it is the main anti-aging drug (vayasthaprana) or the best among rejuvenating herbs; it has properties such as rasayana (adaptogen), ajara (utility in aging), ayushprada (prolonging life of cells) sandhaniya (improves cell migration and cell binding) and kantikara (improves skin tone) 20. Amalaki, which is a source of vitamin C, minerals and amino acids, contains numerous phenolic compounds with antioxidant action. The amalaki extract protects the fibroblasts of the human dermis against oxidative stress and is therefore useful for the natural care of the skin. Vitamin C contributes to the formation of collagen and to guarantee a normal skin function.In a recent study, the effects of amalaki extract on human skin fibroblasts were evaluated, in particular for the production of metalloproteinases of procollagen and matrix21.Amalaki induced the production of procollagene, making itself suitable in anti-aging cosmetic products, for sun protection and for general skin care.Amalaki has a high concentration of natural vitamin C that is essential for the formation of collagen and for the integrity of the connective tissue. It intervenes as a confactor in the reaction of hydroxylation of the proline and lysine amino acids with consequent stabilization of the collagen.Another study suggests that the amalaki extract effectively inhibits the photo-aging induced by the UVB rays in the human skin fibroblast through the strong scavenging ability of the ROS 22 About care of beauty it is used to nourish and revitalize the hair on which they have an astringent and purifying effect.
Ocimum sanctum (tulsi, holy, basil) also known as Holy Basil, is the second Indian herb of Skin Collagen, well known for its medicinal properties. It is a variety of basilica, its name means "the incomparable" and it is part of the fundamental elements of Ayurvedic medicine thanks to its immunostimulant properties, able to enhance our immune system and fight tiredness and psychophysical stress.23 Scientific studies have recognised the uses of traditional medicine. Its strong antioxidant 24and antibacterial 25 action is indicated, which makes it an excellent natural remedy for acne and other skin irritations. In a recent study it was evaluated its antibacterial action and its possibility of being used in the treatment of acne vulgaris for its action against Proprionibacterium acnes. Tulsi showed a powerful antibacterial effect on Proprionibacterium acnes with excellent values of minimum inhibitory concentration.25
EGGS MEMBRANE: PIGMENTATION AND ELASTICITY
New component in powder has been obtained by removing the internal membrane of hen's eggs (Ovoderm®) which represents a natural protective barrier with many beneficial health effects: consisting of collagen (33-38%) of type I, it is the most required by the vascular system, skin, tendons, ligaments, cartilages and bones, sulphured amino acids (10%) that are important for the synthesis of glutathione and other endogenous antioxidants, hyaluronic acid (4%) and chondroitin sulfate (2%) to protect the cartilage and glucosamine (2%) that has both a role in maintaining the integrity of cartilages and activates the synthesis of collagen, keratin (1%) rich in sulphured amino acids able to ensure the stiffness and solidity of body hair, nails and hair and lysozyme (1%) that is an enzyme with antibacterial actions and a powerful activator of the immune system. A clinical study showed as result of intake of Ovoderm® (300mg), An improvement of all biophysical criteria of the skin as pigmentation and elasticity was showed by a clinical study as result of intake of Ovoderm® (300mg) : increasing in elasticity and decreasing of pigmentation (3.8%) thanks to Multi Dermascope MSD 800. The study revealed a statistically significant improvement in skin elasticity, as the skin's ability to reacquire its original shape after having undergone stretching or pressure and a tendency to reduce skin pigmentation (5% reduction). In a second study we measured the effect of the 5-week treatment on hydration by corneometry which allowed to obtain an indirect measurement of the water content of the stratum corneum through the determination of its capacitive properties, and on the elasticity through the cutometer and skin elastometry studies. The study has showed an improvement in the condition of skin hydration, with increasing nail hardness and strength, strengthening the hair and scalp. 26
1. Ichikawa, Satomi, et al. "Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate." International Journal of Food Sciences and Nutrition 61.1 (2010): 52-60.
2. Zague, Vivian. "A new view concerning the effects of collagen hydrolysate intake on skin properties." Archives of dermatological research 300.9 (2008): 479-483.
3. Zague, Vivian, et al. "Collagen hydrolysate intake increases skin collagen expression and suppresses matrix metalloproteinase 2 activity." Journal of medicinal food 14.6 (2011): 618-624.
4. Matsuda, Naoya, et al. "Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis." Journal of nutritional science and vitaminology 52.3 (2006): 211-215.
5. Tanaka, Midori, Yoh-ichi Koyama, and Yoshihiro Nomura. "Effects of collagen peptide ingestion on UV-B-induced skin damage." Bioscience, biotechnology, and biochemistry 73.4 (2009): 930-932.
6. Koyama, Y., et al. "Effects of oral ingestion of collagen peptide on the skin." J Fragr 6 (2006): 82-85.
7. Morganti, P. "Oral treatment of skin dryness." Cosmet Toilet 103 (1988): 77-80.
8. Sumida, E., et al. "The effect of oral ingestion of collagen peptide on skin hydration and biochemical data of blood." J Nutr Food 7.3 (2004): 45-52.
9. Béguin, Alain. "A novel micronutrient supplement in skin aging: a randomized placebo controlled double blind study." Journal of cosmetic dermatology 4.4 (2005): 277-284.
10. Borumand, Maryam, and Sara Sibilla. "Effects of a nutritional supplement containing collagen peptides on skin elasticity, hydration and wrinkles." Journal of Medical Nutrition and Nutraceuticals 4.1 (2015):47.
11. Proksch, E., et al. "Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study." Skin pharmacology and physiology 27.1 (2014): 47-55.
12. Sgouros, Dimitrios, Alexander Katoulis, and Dimitrios Rigopoulos. "Novel topical agent containing superoxide dismutase 100 000 IU and 4% of plant extracts as a mono therapy for atopic dermatitis." Journal of cosmetic dermatology (2017).
13. Indo, Hiroko P., et al. "A mitochondrial superoxide theory for oxidative stress diseases and aging." Journal of clinical biochemistry and nutrition 56.1 (2015): 1-7.
14. Oh, Chang Taek, et al. "Superoxide dismutase 1 inhibits alpha-melanocyte stimulating hormone and ultraviolet B-induced melanogenesis in murine skin." Annals of dermatology 26.6 (2014): 681-687.
15. Li, Xiaoling, et al. "EGF and curcumin co-encapsulated nanoparticle/hydrogel system as potent skin regeneration agent." International journal of nanomedicine 11 (2016): 3993.
16. Purpura, Martin, et al. "Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects." European journal of nutrition (2017): 1-10
17. Barbulova, Ani, Gabriella Colucci, and Fabio Apone. "New trends in cosmetics: By-products of plant origin and their potential use as cosmetic active ingredients." Cosmetics 2.2 (2015): 82-92.
18. Soeur, J., et al. "Skin resistance to oxidative stress induced by resveratrol: from Nrf2 activation to GSH biosynthesis." Free Radical Biology and Medicine 78 (2015): 213-223.
19. Baxter, Richard A. "Anti aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation." Journal of cosmetic dermatology 7.1 (2008): 2-7.
20. Datta, Hema Sharma, and Rangesh Paramesh. "Trends in aging and skin care: Ayurvedic concepts." Journal of Ayurveda and integrative medicine 1.2 (2010): 110.
21. Fujii, Takashi, et al. "Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts." Journal of ethnopharmacology 119.1 (2008): 53-57.
22. Adil, Mushtaq D., et al. "Effect of Emblica officinalis (fruit) against UVB-induced photo-aging in human skin fibroblasts." Journal of Ethnopharmacology 132.1 (2010): 109-114.
23. Das, Subir Kumar, and D. M. Vasudevan. "Tulsi: The Indian holy power plant." (2006).
24. Juntachote, T., et al. "The antioxidative properties of Holy basil and Galangal in cooked ground pork." Meat science 72.3 (2006): 446-456.
25. Viyoch, J., et al. "Evaluation of in vitro antimicrobial activity of Thai basil oils and their micro emulsion formulas against Propionibacterium acnes." International journal of cosmetic science 28.2 (2006): 125-133.
26. Aguirre, Andrés, et al. "Beneficial Effects of Oral Supplementation with Ovoderm on Human Skin Physiology: Two Pilot Studies." Journal of dietarysupplements 14.6 (2017): 706-714.
Amin Biodiet Collagen® thanks to its contents is integrated perfectly with Skin Collagen®. It is a food supplement based on MSM (Methyl Sulfonyl Methane), Bamboo e.s. tit 70% in Silicon, Nettle leaves e.s. tit. 2% in Silicon, Vitamin C, Vitamin E.
The synthesis of collagen depends on the silicon present in the Amin Biodiet Collagen®
Collagen protein consists essentially of 3 amino acids: glycine, proline and hydroxyproline. Our body produces its own collagen every day, but as production decreases with age, the available quantity of collagen quickly becomes insufficient and the different parts of the body gradually deteriorate. Hydroxyproline, which is crucial for the stability of collagen, is synthesized by hydroxylation of the amino acid proline; the reaction requires organic silicon and Vitamin C to allow the addition of oxygen.Nowadays, feeding is typically poor in silicon. The highest percentage of organic silicon is found in bamboo; the nettle contains a fair amount of it and favors its absorption.
Silicon is a structural element of the connective tissue and it is part of the main macromolecules such as elastin, collagen, proteoglycans and glycoproteins, promoting their regeneration. The silicon content is closely related to the optimal skin conditions, such as the rate of hydration, elasticity, absence of wrinkles and lines of expression, scarring and regeneration capacity. It also acts as a metabolic protector, acting at various levels:
MSM (Methyl Sulfonyl Methane) is a form of biologically active sulfur, practically our body can be integrated with organic sulfur in its natural form, with no allergic side effects. It is commonly called "mineral of beauty" because it makes the hair shiny and soft and the skin clear and young.
MSM (Methyl Sulphonyl Methane) restores the formation of cross-links in collagen preserving its elasticity; it is considered a synergistic element in the stimulation of collagen synthesis for the amino acids cystine, glycine, hydroxyproline, ornithine alpha-ketoglutarate and silicon. MSM is also a powerful antioxidant, able to hindering and deactivating the action of free radicals.
Vitamin E, together with Vitamin C, is a powerful antioxidant; as it is protected by the destructive cells of free radicals, it is essential for the stability of collagen.
Skin Collagen® is available in pack sizes of 30 water soluble powder sachets. Amin Biodiet Collagen® is available in pack sizes of 30 tablets. It is recommend to take one sachet of Skin Collagen ® a day (to be dissolved in water or in a liquid food at room temperature) together with a tablet of Amin Biodiet Collagen®