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Colplus

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COLPLUS is a dietary supplement based on:

  • HydrolyzedPig Collagen: hydrolyzed collagen of porcine origin is easily used by human for optimal histocompatibility: compared to other animals, the pig has a genome very similar to the human one, that's why the pig collagen compared to that of bovine origin, marine origin, etc., is much more compatible with humans;
  • Vitamin C: essential to increase the synthesis of collagen
  • Vitamin D:essential for the absorption of calcium and for the bone remodeling processes, stimulating the activity of osteoblasts.

Collagen is by definition the “glue” of our organism; is the most abundant protein in the human body (about 25% of the protein mass) and holds together the tissues of our body, forming the tissue structure of the locomotor system (bones, cartilage, muscles, tendons, ligaments), tissues of protection and support (skin and subcutis), but also of tissues with specific functions (gums, dentine ...).

 

The triple helix of collagen is made compact and stable by a particular sequence of amino acids: every three amino acids the third is Glycine and most of the remaining amino acids are made of Proline and Hydroxyproline

 



The percentage of protein content in the various tissues is as follows:

  • skin e subcutis 72%
  • cartilage  50%
  • bones 23%

 

It is a fibrous protein, endowed with remarkable tensile strength, present in the intercellular substance, which makes tissuesvery resistant and elastic

What factors can cause a loss of collagen?

  • Age: around 25 years of age cells begin to lose the ability to synthesize collagen, whose production falls by 1.5% a year. This process becomes more pronounced over 45 years, and when approaching 60, the production of collagen has decreased more than 35%.
  • Excessive use of the osteo-articular-muscular system: intense physical activity can cause premature joint aging
  • Trauma: for example, when tendons and / or ligaments that are in or around the joints suffer a trauma, the collagen fibers are pulled and twisted beyond their physiological limit, causing moreover the pain (the "collagen" is a fundamental component of the material of support of bones and joints and not only, and if our body has the possibility of producing fibers of  collagen as a result, collagen can rejuvenate the soft tissues and also helps eliminate the pain).Or , in case of fracture, there is an interruption of the integrity of the bone, and the organism must therefore start producing more collagen to repair it.
  • Menopause: period in which the reduction of hormonal levels, in particular a deficiency of estrogen, causes an increased deterioration of collagen consumption.
  • Nutrition: in case of the lack of vitamin C and silicon, essential for the synthesis of collagen

 

 

The loss of collagen is one of the factors causing the onset of degenerative disease states as:

  • Arthrosis: a degenerative disease that affects the joints, leading to the progressive loss of their normal anatomical components. It mainly affects the vertebrae and limbs joints, and it is characterized by the loss of articular cartilage, which is replaced by new bone tissue. Collagen constitutes 50% of cartilage weight, and therefore its loss causes thinning and decrease in the consistency of the same, resulting in an arthritic process.
  • Osteoporosis: a systemic disease of the skeleton, characterized by a reduction in bone mass and deterioration of the microarchitecture of bone tissue, which leads to an increased frailty and predisposition to fractures, especially in old age. Collagen constitutes 30% of the organic bone matter and the support where calcium salts are fixed; when the bone collagen matrix deteriorates, calcium salts are dispersed (decalcification) and, despite a supplement with calcium and vitamin D, said matrix can not be remineralized if it is not regenerated first.
  • Ligament and muscle-tendon injuries: collagen accounts for 80% of the weight of the tendons, ligaments and connective tissue associated with the muscles. Its loss favours the onset of tendinopathies, sprains and muscle injuries.
  • Aging of the dermis: collagen makes up 70% of the weight of the epidermis.

 

  Hydrolyzed Pig Collagen (CH)contained in the COLPLUSÒ has the following nutritional features:

  • It provides 16% of essential amino acids (in its composition are all present, excepttryptophan).
  • It supplies 60% of conditionally essential amino acids (essential in case of cellular stress, for aging of collagen or overloading and its excessive use), especially the amino acids typical of the amino acid chain of collagen (Glycine, Proline, Hydroxyproline, Hydroxylisine), which make up 49% of the product
  • It contains glycine, arginine and methionine that are 3 amino acids precursors of creatine synthesis (ATP regenerants, source of muscle energy).

COLPLUSÒ is a protein nutrient producing an increased synthesis of tissue collagen and other components of the extracellular matrix, acting as a regenerator of the collagen tissue.

In its hydrolysed form, the pig collagen has a particularly low average molecular weight, and it is characterized by a high food absorption

Bioavailability studies show that intestinal absorption of ingested CH rises to 82% in the first 6 hours after ingestion (1) and to 95% in 12 hours (2) .In rats: 12 hours after the administration of a dose of collagen hydrolysed with C14 isotope marker in the cartilage of the rat (C)  the radioactivity is twice that of the one accumulated when the only labeled proline is ingested. Moreover, in the cartilage (C), the radioactive signal is maintained in 96 hours, which indicates a considerable concentration and permanence of the hydrolyzed collagen in the cartilaginous tissue. This effect is not seen in plasma (P) or in other tissues (2):

 



Comparative study of the effectiveness of hydrolyzed collagen andglucosamine in gonarthrosis

A mixed group of 100 men and women of about 40 years with gonarthrosis underwent 13-week treatment with 10 g of CH a day or with _1.5 g of GS (Glucosamine Sulfate). Results were obtained following 3 criteria: WOMAC O.S. index, Quadruple VAS P.I. and QLSF._The group treated with CH obtained the best results (p <0.05) of all the parameters in reference. So we can state that  CH has greater clinical efficacy than GS in knee osteoarthritis, with significant differences regarding the improvement of pain, joint function and quality of life. (3)



Study about protein intake in old age

The addition of a CH supplement prescribed to patients with pressure ulcers (grade II to IV) doubled the rate of recovery compared to a control group that received placebo treatment, as indicated by the values PUSH (Pressure Ulcer Scale for Healing), measured after 8 weeks from the beginning of therapy, with better results in the CH group (4) (Figure 1). As regard to whey protein, CH preserves muscle mass in the case of a protein-restricted normocaloric diet, as usually occurs in old age (5) and also maintains a good balance of nitrogen both in the normocaloric (5) and low-calorie diet (6). So a supplement of CH in the diet is shown preventing complications and helping in decreasing mortality of vulnerable old age people, especially if forced to rest or in case of sarcopenia. (7)

 

VITAMIN C: it is a water-soluble vitamin and it is essential for the synthesis of collagen as it intervenes in the conversion of Proline into Hydroxyproline and Lysine in Hydroxylysine (reactions catalyzed by the enzymes proline hydroxylase and lysine hydroxylase, respectively), crucial amino acids for the stability of the collagen .

It must be taken with food, as man is among the few animal species that are not able to synthesize it. The name "ascorbic acid" recalls the ability of this vitamin to cure scurvy, a disease that particularly affected the crews of ships that, for long distances, could not consume fresh fruit and vegetables.

 

VITAMIN C:

  • it participates in making up collagen and intercellular matrix facilitating the robustness of cartilages, bones, dentin and blood vessel wall;

  • it helps the absorption of intestinal iron;

• it stimulates the immune system and protects against infections;

• it prevents many substances from turning into carcinogens;

  • it acts as an antioxidant (thus protecting cells from free radicals doing their job distructive) and enhances the effects of other antioxidants, such as vitamin A, vitamin E, selenium;

  • it is essential for hormone synthesis;

  • it intervenes in reducing the levels of LHL cholesterol;

  • it is useful in the prevention and treatment of allergies.

 

VITAMIN D: itis oneof liposoluble vitamins; it is essential for the absorption of calcium and for the bone remodeling processes, stimulating the activity of osteoblasts.

Its discovery dates back to 1918 following the observation that fish oil and sunlight had a healing effect on rickets (severe skeletal pathology). In fact, the main feature of this vitamin is that it can be introduced as such with food or it can be synthesized in our body at the level of the skin through sun exposure (for this reason it is also called "sun ray vitamin") .

It is a vitamin with numerous and important functions:

• It intervenes in the absorption of calcium and phosphorus at the intestinal level;

• It regulates bone mineralization;

• It promotes regular growth and development of bones and teeth;

• It is able to influence the secretion of different hormones by controlling the level of calcium in the cells;

• It plays an important role in modulating the functioning of the immune system

 

Experimental data have shown that Vitamin D deficiency can cause:

• weakening of bones with deformations (rickets in childhood) and fractures (osteomalacia and osteoporosis in adulthood);

• increased risk of infections;

• muscle weakness;

• mental asthenia;

• muscle spasms.

 

COLPLUSÒis available in pack sizes of 30 sachets of 10.4 g of soluble powder. It does not contain fats, sugars, sweeteners, dyes or preservatives. The recommended daily dose is 1 sachet a day that can be dissolved in a liquid food (water, yogurt, milk, etc.) at room temperature or warm, preferably at night, at least 1 hour after dinner. It does not raise any intolerances, side effects or drug/supplement incompatibility; it is just contraindicated in patients with phenylketonuria and the reason is easily understood: the recommended daily dose brings 230 mg of phenylalanine, an essential amino acid naturally occurring in collagen. Finally, like all protein products, it can be taken by people on a low protein diet because affected by kidney problems or serious liver diseases ,only under strict medical supervision.

  1. Zeijdner E.E. "Digestibility of collagen hydrolysate during passage through a dynamic gastric and small intestinal model (TIM-1) ". TNO Nutrition and food Research Report. 24 June 2002.
  2. Oesser S., Adam M., Babel W. and Seifert J. "Oral Administration of 14C Labelled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)" American Society for Nutritional Sciences.1999:1891-1895.
  3. Trc T, Bohmova J. "Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA)". Int Orthop.2011;35:341--8.
  4. Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. "Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: A randomized controlled trial" .Adv Skin Wound Care. 2006;19:92-96.
  5. Hays NPI, Kim H, Wells AM, Kajkenova O, Evans WJ. "Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older women" J Am Diet Assoc. 2009 Jun;109(6):1082-7.
  6. Gougeon R "The metabolic response to two very low energy diets (VLED) of differing amino acid composition during weight reduction" Int J Obes Relat Metab Disord. 1992;16:1005-1012.
  7. Weh L., Petau C. "Change in the Properties of Tissue through the Administration of Gelatine. A Biomechanica Pilot Study". Extracta orthopaedica. 2001; 4: 12-16.

 

 

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